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你正在浏览BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献
  • Combination of gp130-targeting and TNF-targeting small molecules in alleviating arthritis through the down-regulation of Th17 differentiation and osteoclastogenesis.

    abstract：:Rheumatoid arthritis (RA) is a systemic, chronic inflammatory disease that is characterized by T helper 17 (Th17) cell- and osteoclast-induced joint destruction and inflammation. In RA, several cytokines (interleukin (IL)-1, 6,17, and tumor necrosis factor (TNF)) are involved in almost all aspects of articular inflamm...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.11.183

    authors： Park YH,Kim HJ,Lee K,Choi Y,Heo TH

    更新日期：2020-02-19 00:00:00

  • Unraveling the molecular mechanism of BNC105, a phase II clinical trial vascular disrupting agent, provides insights into drug design.

    abstract：:Microtubules are made up of tubulin protein and play a very important part in numerous cellular events of eukaryotic cells, which is why they are seen as attractive targets for tumor chemotherapy. BNC105, a known vascular targeting agent, has entered in phase II clinical trials. It has previously been confirmed that B...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.12.083

    authors： Wang T,Wu C,Wang C,Zhang G,Arnst KE,Yao Y,Zhang Z,Wang Y,Pu D,Li W

    更新日期：2020-02-18 00:00:00

  • Mutations of histone demethylase genes encoded by X and Y chromosomes, Kdm5c and Kdm5d, lead to noncompaction cardiomyopathy in mice.

    abstract：:Mammalian X and Y chromosomes evolved from a pair of autosomes. Although most ancestral genes have been lost from the Y chromosome, a small number of ancestral X-Y gene pairs are still present on the sex chromosomes. The KDM5C and KDM5D genes, which encode H3K4 histone demethylases, are a surviving ancestral gene pair...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.02.043

    authors： Kosugi M,Otani M,Kikkawa Y,Itakura Y,Sakai K,Ito T,Toyoda M,Sekita Y,Kimura T

    更新日期：2020-02-17 00:00:00

  • The casein kinase 2α promotes the occurrence polycystic ovary syndrome.

    abstract：:Polycystic ovary syndrome (PCOS) is a complicated reproductive endocrine disease characterized by hyperandrogenism, polycystic ovaries, and anovulation. Previous studies have revealed that androgen receptors (ARs) are strongly associated with hyperandrogenism and abnormalities in folliculogenesis in patients with PCOS...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.02.065

    authors： Yu CJ,Liu X,Zhou ZY,Chen XJ,Meng YC,Gu HC,Xu JJ,Ding GL,Liu XM,Sheng JZ,Huang HF

    更新日期：2020-02-17 00:00:00

  • DNA methylation status influences insulin-induced glucose transport in 3T3-L1 adipocytes by mediating p53 expression.

    abstract：:Researchers frequently use 3T3-L1 adipocytes as a fat cell line, but the capacity of this line for insulin-mediated glucose transport is lower than that of primary isolated fat cells. In this study, we found that 5-azacytidine (5-aza-C), DNA methyltransferase 1 inhibitor, enhanced insulin-stimulated 2-deoxyglucose (2-...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.02.038

    authors： Kuroda M,Onoyama R,Sasaki W,Sebe M,Kitamura T,Masumoto S,Tsutsumi R,Harada N,Sakaue H

    更新日期：2020-02-16 00:00:00

  • Intracellular cAMP contents regulate NAMPT expression via induction of C/EBPβ in adipocytes.

    abstract：:A decline in intracellular nicotinamide adenine mononucleotide (NAD+) causes adipose tissue dysfunction. Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the rate-limiting step in the NAD+ biosynthesis pathway. However, the molecular mechanism that mediates regulation of NAMPT expression in adipocytes is yet t...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.11.165

    authors： Mitani T,Watanabe S,Wada K,Fujii H,Nakamura S,Katayama S

    更新日期：2020-02-12 00:00:00

  • Inhibition of DNA-PKcs activity re-sensitizes uveal melanoma cells to radio- and chemotherapy.

    abstract：:Uveal melanoma (UM) is the most common primary intraocular tumor in adults. Despite of important progress in the local therapy, high radioresistance in primary tumor and chemoresistance in metastatic disease are the major obstacles for UM therapy. Therefore, strategies to overcome resistance to radiation or chemothera...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.11.133

    authors： Zhang B,Wu H,Hao J,Wu Y,Yang B

    更新日期：2020-02-12 00:00:00

  • Decreased cpg15 augments oxidative stress in sleep deprived mouse brain.

    abstract：:Sleep deprivation (SD) has detrimental effects on the physiological function of the brain. However, the underlying mechanism remains elusive. In the present study, we investigated the expression of candidate plasticity-related gene 15 (cpg15), a neurotrophic gene, and its potential role in SD using a REM-SD mouse mode...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.11.132

    authors： Li CJ,Li JJ,Jiang Y,Mu YW,Lu DX,Xiao ZY,Jiang HY,Zhao JJ,Chen XH

    更新日期：2020-02-12 00:00:00

  • The BRCC3 regulated by Cdk5 promotes the activation of neuronal NLRP3 inflammasome in Parkinson's disease models.

    abstract：:BRCA1-BRCA2-containing complex subunit 3 (BRCC3), a Lys-63-specific deubiquitinase, is a member of the JAMM/MPN family of zinc metalloproteases. BRCC3 have been shown to promote the inflammasome activation by deubiquitinating NOD-like receptor containing pyrin domain 3 (NLRP3). We reported the involvement of neuronal ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.11.141

    authors： Cheng X,Xu S,Zhang C,Qin K,Yan J,Shao X

    更新日期：2020-02-12 00:00:00

  • Doxorubicin inhibits PD-L1 expression by enhancing TTP-mediated decay of PD-L1 mRNA in cancer cells.

    abstract：:Recent research revealed that doxorubicin (DOX) decreased expression of programmed death-ligand 1 (PD-L1) in cancer cells. However, the detailed mechanisms underlying this effect are not well established. Here, we demonstrate that doxorubicin down-regulates PD-L1 expression through induction of AU-rich element (ARE) b...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.11.106

    authors： Kim DJ,Jang JH,Ham SY,Choi SH,Park SS,Jeong SY,Kim BC,Jeon DY,Lee BJ,Ko BK,Park JW,Cho WJ

    更新日期：2020-02-05 00:00:00

  • The impact of N-cadherin-β-catenin signaling on the analgesic effects of glial cell-derived neurotrophic factor in neuropathic pain.

    abstract：:Long-term neuropathic pain can lead to anxiety, depression, and other issues, which seriously affect patients' quality of life. For this reason, it is important to find effective treatments. Studies have shown that glial cell-derived neurotrophic factor (GDNF) can relieve neuropathic pain. However, its mechanism of ac...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.11.076

    authors： Pan Y,Jiang L,Wang C

    更新日期：2020-02-05 00:00:00

  • B cell ADAM17 controls T cell independent humoral immune responses through regulation of TACI and CD138.

    abstract：:ADAM17 is known to contribute to the immune system through its shedding of tumor necrosis factor alpha (TNFα). However, the role of ADAM17 in B cell biology is not well characterized. To determine whether B cell ADAM17 contributes to T cell-independent humoral immune responses, we crossed CD19 Cre transgenic mice with...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.11.124

    authors： Lownik JC,Wimberly JL,Takahashi-Ruiz L,Martin RK

    更新日期：2020-02-05 00:00:00

  • Molecular characterization of the orphan transporter SLC16A9, an extracellular pH- and Na+-sensitive creatine transporter.

    abstract：:Human monocarboxylate transporters (hMCTs) mediate the transport of monocarboxylates across plasma membranes. One such transporter, hMCT9, has been shown to be related to serum uric acid levels and the risk of renal overload gout. However, the functional characteristics of hMCT9 remain unknown. The aim of this study w...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.11.137

    authors： Futagi Y,Narumi K,Furugen A,Kobayashi M,Iseki K

    更新日期：2020-02-05 00:00:00

  • Diethylnitrosamine and thioacetamide-induced hepatic damage and early carcinogenesis in rats: Role of Nrf2 activator dimethyl fumarate and NLRP3 inhibitor glibenclamide.

    abstract：:Two-stage rat hepatocarcinogenesis model was used to induce early carcinogenesis in which thioacetamide (TAA) promotes diethylnitrosamine (DEN) initiated carcinogenesis. Dimethyl fumarate (DMF) used to treat multiple sclerosis, activates the nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant responsive ele...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.11.100

    authors： Dwivedi DK,Jena GB

    更新日期：2020-02-05 00:00:00

  • Number and molecular brightness analysis reveals Htt25Q protein aggregation upon the uptake of Htt97Q aggregates.

    abstract：:Number and molecular Brightness (N&B) analysis is a powerful method used to monitor protein aggregation in living cells. Here, we used the N&B method to characterize the unexpanded HTT protein oligomerization after the internalization of the mutant HTT (mHTT) which contains a CAG repeat extensions encoding for long po...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.10.041

    authors： Sameni S,Zhang R,Digman MA

    更新日期：2020-01-29 00:00:00

  • ATP is a cryptic binder of TDP-43 RRM domains to enhance stability and inhibit ALS/AD-associated fibrillation.

    abstract：:ATP is the universal energy currency for all cells but has cellular concentrations of 2-12 mM, much higher than required for its classic functions. RNA-recognition motif (RRM) constitutes one of the most abundant domains in eukaryotes and most heterogeneous nuclear ribonucleoproteins (hnRNP) contain RRM domains which ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.11.088

    authors： Dang M,Kang J,Lim L,Li Y,Wang L,Song J

    更新日期：2020-01-29 00:00:00

  • Heparin improves alveolarization and vascular development in hyperoxia-induced bronchopulmonary dysplasia by inhibiting neutrophil extracellular traps.

    abstract：:The objective of this study was to assess the role of NETs in BPD of hyperoxia-induced rat model and the effect of heparin on alveolarization and vascular development in BPD. The neonatal rats exposed to 90% oxygen continuously for 7 days to mimic BPD, meanwhile, the rats were injected by different doses of histones t...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.11.041

    authors： Sun Y,Chen C,Zhang X,Wang S,Zhu R,Zhou A,Chen S,Feng J

    更新日期：2020-01-29 00:00:00

  • Leukemia inhibitory factor induces corticotropin-releasing hormone in mouse trophoblast stem cells.

    abstract：:Previous studies have shown that some inflammatory cytokines promote the expression of corticotropin-releasing hormone (CRH) in trophoblasts during pregnancy and that placental CRH could induce the production of adrenocorticotropic hormone (ACTH) in humans. However, whether the same is true in rodent placenta remains ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.11.059

    authors： Wang H,Tsukada T,Shimada H,Sakata-Haga H,Iida Y,Zhang S,Shoji H,Hatta T

    更新日期：2020-01-29 00:00:00

  • Non-small cell lung cancer cells with deficiencies in homologous recombination genes are sensitive to PARP inhibitors.

    abstract：:Lung cancer is the leading cause of cancer death worldwide. PARP inhibitors have become a new line of cancer therapy and a successful demonstration of the synthetic lethality concept. The mechanism and efficacy of PARP inhibitors have been well studied in some cancers, especially homologous recombination (HR)-deficien...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.11.050

    authors： Ji W,Weng X,Xu D,Cai S,Lou H,Ding L

    更新日期：2020-01-29 00:00:00

  • Biochemical thresholds for pathological presentation of ATP synthase deficiencies.

    abstract：:Mitochondrial ATP synthase is responsible for production of the majority of cellular ATP. Disorders of ATP synthase in humans can be caused by numerous mutations in both structural subunits and specific assembly factors. They are associated with variable pathogenicity and clinical phenotypes ranging from mild to the m...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.11.033

    authors： Nuskova H,Mikesova J,Efimova I,Pecinova A,Pecina P,Drahota Z,Houstek J,Mracek T

    更新日期：2020-01-22 00:00:00

  • The follicle promotes the evolution of variants of avian leukosis virus subgroup J in vertical transmission.

    abstract：:Avian leukosis virus (ALV) is one of the main causative agent of tumor development, which brings enormous economic losses to the poultry industry worldwide. ALV can be transmitted horizontally and vertically, and the latter often give rise to more adverse pathogenicity. However, the propagation and evolution of ALV un...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.11.042

    authors： Gao X,Li Q,Fang L,Song H,Cui Z,Meng F,Zhang Z

    更新日期：2020-01-22 00:00:00

  • BET inhibitor bromosporine enhances 5-FU effect in colorectal cancer cells.

    abstract：:Treatment of colorectal cancer (CRC) remains a challenge because of the lack of effective early treatment strategies and high incidence of relapse. 5-Fluorouracil (5-FU) is a typical CRC treatment. Bromosporine is an innovative bromodomain and extraterminal domain (BET) inhibitor. We investigated if CRC could be targe...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.11.009

    authors： Cheng X,Huang Z,Long D,Jin W

    更新日期：2020-01-22 00:00:00

  • Establishment of a novel method for the identification of fertilization defective mutants in Arabidopsis thaliana.

    abstract：:Plant reproduction is an extremely important phenomenon, as it is strongly associated with plant genetics and early development. Additionally, foundations of the reproductive system have direct implications on plant breeding and agriculture. Investigation of the functions of male and female gametophytes is critical si...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.11.028

    authors： Liu X,Wu X,Adhikari PB,Zhu S,Kinoshita Y,Berger F,Higashiyama T,Kasahara RD

    更新日期：2020-01-22 00:00:00

  • Glycosylation is a novel TGFβ1-independent post-translational modification of Smad2.

    abstract：:Smad2 is a crucial component of intracellular signaling by transforming growth factor-β (TGFβ). Here we describe that Smad2 is glycosylated, which is a novel for Smad2 post-translational modification. We showed that the Smad2 glycosylation was inhibited upon treatment of cells with 17β-estradiol, and was enhanced in c...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.11.039

    authors： Gotoh T,Iwahana H,Kannan S,Marei RG,Mousa H,Elgamal M,Souchelnytskyi S

    更新日期：2020-01-22 00:00:00

  • Interaction of cavin-1/PTRF leucine zipper domain 2 and its congenital generalized lipodystrophy mutant with model membranes.

    abstract：:The organization of caveolae ultrastructures in the plasma membrane and the functions they dictate are mediated by membrane-embedded caveolins (caveolin-1, 2, 3) and peripherally attached cavins (cavin-1, 2, 3, 4). Mutations in caveolin and cavin genes are associated with a variety of human diseases. Cavin-1/PTRF muta...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.10.167

    authors： Mohapatra A,Lokappa SB,Chaudhary N

    更新日期：2020-01-15 00:00:00

  • Effect of potassium ions at the different concentration on the interaction between AmB and the lipid monolayer containing cholesterol or ergosterol.

    abstract：:AmB is an antifungal drug of polyene. Although it is prone to nephrotoxicity, it is still the gold standard in the clinical treatment of fungal infection. Sterol plays a decisive role in the drug activity of AmB. The antifungal activity of AmB depends on ergosterol in fungal membranes, and its toxicity is related to c...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.10.166

    authors： Wang J,Ma Y,Hou S

    更新日期：2020-01-15 00:00:00

  • K562 cell-derived exosomes suppress the adhesive function of bone marrow mesenchymal stem cells via delivery of miR-711.

    abstract：:A failure of bone marrow mesenchymal stem cells (BM-MSCs) to adhere to hematopoietic cells is an essential cause of the progression of chronic myelogenous leukemia and is also a cause of failure of bone marrow (BM) transplantation, but the exact mechanisms of this have not been fully elucidated. Recent studies have in...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.10.096

    authors： Jiang YH,Liu J,Lin J,Li SQ,Xu YM,Min QH,Zhong QH,Sun F,Li J,You XH,Liao KL,Qin TY,Zhao C,Huang B,Wang XZ

    更新日期：2020-01-15 00:00:00

  • Tadalafil alleviates preeclampsia and fetal growth restriction in RUPP model of preeclampsia in mice.

    abstract：BACKGROUND:- Tadalafil, a long-acting phosphodiesterase 5 (PDE5) inhibitor, alleviates preeclampsia (PE), and decreases the fetal and infant deaths associated with fetal growth restriction (FGR) in phase II clinical trial. Recently, we demonstrated that tadalafil alleviates FGR and hypertension in the dams with PE indu...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.10.186

    authors： Sekimoto A,Tanaka K,Hashizume Y,Sato E,Sato H,Ikeda T,Takahashi N

    更新日期：2020-01-15 00:00:00

  • O-GlcNAcylation-mediated degradation of FBXL2 stabilizes FOXM1 to induce cancer progression.

    abstract：:O-GlcNAcylation is a dynamic and reversible post-translational modification of cytonuclear molecules that regulates cellular signaling. Elevated O-GlcNAcylation is a general property of cancer and plays a critical role in cancer progression. We previously showed that the expression of FOXM1, a critical oncogenic trans...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.10.164

    authors： Ueda Y,Moriwaki K,Takeuchi T,Higuchi K,Asahi M

    更新日期：2020-01-15 00:00:00

  • LncRNA PCAT6 promotes tumor progression in osteosarcoma via activation of TGF-β pathway by sponging miR-185-5p.

    abstract：:Long noncoding RNAs (lncRNAs) play crucial roles in tumor development of osteosarcoma (OS). LncRNA PCAT6 was involved in the progression of multiple human cancers. However, the biological function of PCAT6 in OS remains largely unknown. We found that PCAT6 was elevated in OS tissues relative to that in their adjacent ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.10.136

    authors： Zhu C,Huang L,Xu F,Li P,Li P,Hu F

    更新日期：2020-01-08 00:00:00

  • Apatinib-loaded nanoparticles inhibit tumor growth and angiogenesis in a model of melanoma.

    abstract：:Anti-angiogenic drugs are an effective therapeutic method for the treatment of melanomas. Apatinib is a small-molecule tyrosine kinase inhibitor, which has potent inhibitory activity on tumor angiogenesis. Due to the low water solubility and stability of Apatinib, we aimed to design and develop poly (lactic-co-glycoli...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.10.084

    authors： Zhang J,Liu P,Zhang Z,Han J,Yang X,Wang A,Zhang X

    更新日期：2020-01-08 00:00:00

  • A defective prostaglandin E synthase could affect egg formation in the silkworm Bombyx mori.

    abstract：:We had previously reported a prostaglandin E synthase (bmPGES) in the silkworm Bombyx mori that catalyzes the isomerization of PGH2 to PGE2. The present study aimed to provide a genome-editing characterization of bmPGES in B. mori. Results showed bmPGES gene disruption to result in a reduced content of PGE2. The chang...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.10.121

    authors： Yamamoto K,Tsubota T,Uno T,Tsujita Y,Yokota S,Sezutsu H,Mita K

    更新日期：2020-01-08 00:00:00

  • Leukocyte recruitment induced by snake venom metalloproteinases: Role of the catalytic domain.

    abstract：:Snake venom metalloproteinases (SVMPs) are key toxins involved in local inflammatory reactions after snakebites. This study aimed to investigate the effect of SVMP domains on the alterations in leukocyte-endothelium interactions in the microcirculation of mouse cremaster muscle. We studied three toxins: BnP1, a PI-tox...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.10.144

    authors： Zychar BC,Clissa PB,Carvalho E,Baldo C,Gonçalves LRC

    更新日期：2020-01-08 00:00:00

  • Induction of pluripotency in mammalian fibroblasts by cell fusion with mouse embryonic stem cells.

    abstract：BACKGROUND:Cell fusion is a phenomenon that is observed in various tissues in vivo, resulting in acquisition of physiological functions such as liver regeneration. Fused cells such as hybridomas have also been produced artificially in vitro. Furthermore, it has been reported that cellular reprogramming can be induced b...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.10.026

    authors： Imai H,Kusakabe KT,Kiso Y,Hattori S,Kai C,Ono E,Kano K

    更新日期：2020-01-01 00:00:00

  • Identification of two additional plasmodesmata localization domains in the tobacco mosaic virus cell-to-cell-movement protein.

    abstract：:Despite decades of intensive studies, the failure to identify plasmodesmata (PD) localization sequences has constrained our understanding of Tobacco mosaic virus (TMV) movement. Recently, we identified the first PD localization signal (major PLS) in the TMV movement protein (MP), which encompasses the first 50 amino a...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.10.093

    authors： Liu Y,Huang C,Zeng J,Yu H,Li Y,Yuan C

    更新日期：2020-01-01 00:00:00

  • Trehalose targets Nrf2 signal to alleviate d-galactose induced aging and improve behavioral ability.

    abstract：:As an important factor leading to aging and chronic diseases, oxidative stress has become a hot research topic. Trehalose is a natural sugar widely found in many edible plants, animals and natural microorganisms, and recent studies have suggested that trehalose is an antioxidant, although its underlying molecular mech...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.10.088

    authors： Sun L,Zhao Q,Xiao Y,Liu X,Li Y,Zhang J,Pan J,Zhang Z

    更新日期：2020-01-01 00:00:00

  • Long noncoding RNA SOX2-OT facilitates prostate cancer cell proliferation and migration via miR-369-3p/CFL2 axis.

    abstract：:Accepted as crucial participators in human malignancies, long noncoding RNAs (lncRNAs) have been proven to exert significant function on the complicated processes of cancer progression. Although existing investigations have revealed the oncogenic role of lncRNA SOX2 overlapping transcript (SOX2-OT) in different kinds ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.09.108

    authors： Wo Q,Zhang D,Hu L,Lyu J,Xiang F,Zheng W,Shou J,Qi X

    更新日期：2019-12-10 00:00:00

  • Epoxyeicosatrienoic acids protect pancreatic beta cells against pro-inflammatory cytokine toxicity.

    abstract：:Pro-inflammatory cytokines contribute to pancreatic beta cell death in the pathogenesis of type 1 diabetes mellitus (DM). Cytochrome P450-derived epoxyeicosatrienoic acids (EETs), produced by selective epoxidation of arachidonic acid, display anti-inflammatory activity in numerous disease models, in part through inhib...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.09.124

    authors： Grimes D,Watson D

    更新日期：2019-12-03 00:00:00

  • Cytoplasmic fusion between an enlarged embryonic stem cell and a somatic cell using a microtunnel device.

    abstract：:Based on a previous finding that fusion of a somatic cell with an embryonic stem (ES) cell reprogrammed the somatic cell, genes for reprogramming transcription factors were selected and induced pluripotent stem (iPS) cell technology was developed. The cell fusion itself produced a tetraploid cell. To avoid nuclear fus...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.09.131

    authors： Kim SM,Wada KI,Ueki M,Hosokawa K,Maeda M,Sakai Y,Ito Y

    更新日期：2019-12-03 00:00:00

  • Toll-like receptor 4 protects against irradiation-induced hematopoietic injury by promoting granulopoiesis and alleviating marrow adipogenesis.

    abstract：:Irradiation induces severe damage in the hematopoietic system, which leads to bone marrow hyperplasia, pancytopenia, and aggravated tissue formation in bone marrow. Studies have shown that Toll-like receptor 4 (TLR4) has a protective effect against irradiation, but the underlying mechanism remains unclear. In this stu...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.10.027

    authors： Sun Z,Wu K,Lin Q,Fei H,Jiang H,Chen T,Yuan Y

    更新日期：2019-12-03 00:00:00

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